Reviews
Natural autoantibodies against G protein-coupled receptors as key for disease predisposition
R. Akbarzadeh1, E.-B. Adjailia2, J.Y. Humrich3, H. Heidecke4, G. Riemekasten5
- Department of Rheumatology and Clinical Immunology, University of Lübeck, Germany.
- Department of Rheumatology and Clinical Immunology, University of Lübeck, Germany.
- Department of Rheumatology and Clinical Immunology, University of Lübeck, Germany.
- CellTrend GmbH, Luckenwalde, Germany.
- Department of Rheumatology and Clinical Immunology, University of Lübeck, Germany. gabriela.riemekasten@uksh.de
CER8
2024 Vol.1, N°2
PI 0045, PF 0052
Reviews
Received: 29/08/2024
Accepted : 02/10/2024
In Press: 11/10/2024
Published: 20/12/2024
Abstract
Antibodies (Abs) targeting G protein-coupled receptors (GPCRs) are a natural component of the immune system. These antibodies reflect the unique GPCR expression profile of the individual, shaped by environmental and non-genetic factors. Due to their tightly regulated levels, GPCR antibodies have emerged as valuable biomarkers across a range of inflammatory diseases. In this review, we explore their crucial role in modulating immune responses, focusing on the mechanisms by which they influence the strength, composition, and localisation of inflammation. These properties position them as key players in determining host-specific susceptibility to various diseases. Importantly, GPCR antibodies can mimic the receptor-mediated signalling found in affected individuals, offering a potential pathway to identify disease-specific mechanisms. Their ability to modulate ligand-GPCR interactions and trigger ligand-independent GPCR activity makes them promising tools for both pharmacological development and precision medicine, particularly in the context of inflammation. This review aims to inspire further research on natural GPCR antibodies, with a special emphasis on mechanistic studies.
